Update History

0.23 (March 5, 2019)

"Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy" by Logtenberg et al. (Nature Medicine, 2019) published

  • - Added screen from the paper:

0.2.3 (Nov. 16, 2017)

"Vasohibins encode tubulin detyrosinating activity" by Nieuwenhuis et al. (Science, 2017) published


0.2.3 (Nov. 8, 2017)

Several optimizations

  • - Updated to Django 1.11.7
  • - Optimized ColumnDataSource for Fishtail plots reducing page size over 50%
  • - Added several indexes to PostgreSQL database for faster queries

0.2.2 (Sept. 12, 2017)

"Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis" by Loregger et al. (ATVB 2017) published


  • - Added screen from the paper:

0.2.2 (Sept. 9, 2017)

Bug fix

  • -Fix bug that caused template render error when trying to make a plot of an intracellular phenotype screen

0.2.1 (Sept. 8, 2017)

Minor updates

  • -Added legend to genefinder
  • -Custom page titles
  • -Gene list now includes links to genefinder

0.2 (Aug. 31, 2017)

Major cosmetic changes and several bugfixes


  • - Switched to Bootstrap v3 resulting in a more responsive layout and improved compatibility with mobile devices
  • - Fixed bug that caused requests to draw a geneplot of a gene that does exist in the database but was never a hit in a screen to result in a 400 (bad request) error/li>
  • - Made several error messages more readable
  • - Fixed bug where extended genenames (such as AGAP9@chr10+) did not result in a valid link to UCSC

0.1 (Aug. 17, 2017)

"Identification of CMTM6 and CMTM4 as PD-L1 protein regulators" by Mezzadra et al. (Nature 2017) published


0.1 (Feb. 9, 2017)

First public version of Phenosaurus and publication of "Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling" by Brockmann et al. (Nature, 2017)


  • - Added all screens from this paper
    • - glycosylated LAMP1
    • - GNB1
    • - GNB1 in KCTD5 knockout
    • - Histone H2A(K119) crotonylation
    • - Histone H3(K27) trimethylation
    • - IRF1
    • - non-phospho-beta-Catenin
    • - phospho-AKT
    • - phospho-AKT in KCTD5 knockout
    • - phospho-ERK
    • - phospho-p38
    • - spliced XBP1

  • - Made the following functionality public:
    • -Interactive fishtail plots
    • -Geneplots

  • - Added documentation

  • - Migrated server to EU and switched to Gunicorn Web Server Gateway Interface