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In 7 screen(s) in human haploid (HAP1) cells EEFSEC was found to be regulator. Specifically, EEFSEC was found to negatively affect the abundance of phospho-ERK, GNB1, PD-L1 and CD47 and positively affect the abundance of phospho-AKT, Histone H3(K27) trimethylation and phospho-AKT in KCTD5 knockout