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In 6 screen(s) in human haploid (HAP1) cells EDC4 was found to be regulator. Specifically, EDC4 was found to negatively affect the abundance of Histone H2A(K119) crotonylation, non-phospho-beta-Catenin, PD-L1, PD-L1 in CMTM6 knockout, deY-Tubulin and CD47