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In 7 screen(s) in human haploid (HAP1) cells EARS2 was found to be regulator. Specifically, EARS2 was found to negatively affect the abundance of Histone H2A(K119) crotonylation and positively affect the abundance of phospho-AKT, glycosylated LAMP1, GNB1 in KCTD5 knockout, PD-L1 in CMTM6 knockout, HMGCR and deY-Tubulin