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In 10 screen(s) in human haploid (HAP1) cells DOT1L was found to be regulator. Specifically, DOT1L was found to negatively affect the abundance of phospho-AKT, Histone H3(K27) trimethylation, non-phospho-beta-Catenin, PD-L1 and deY-Tubulin and positively affect the abundance of phospho-ERK, phospho-p38, IRF1, PD-L1 in CMTM6 knockout and CD47