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In 10 screen(s) in human haploid (HAP1) cells DICER1 was found to be regulator. Specifically, DICER1 was found to negatively affect the abundance of phospho-AKT, glycosylated LAMP1, GNB1, Histone H3(K27) trimethylation, phospho-AKT in KCTD5 knockout, non-phospho-beta-Catenin, PD-L1, IRF1, PD-L1 in CMTM6 knockout and HMGCR