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In 12 screen(s) in human haploid (HAP1) cells DEPDC5 was found to be regulator. Specifically, DEPDC5 was found to negatively affect the abundance of phospho-ERK, glycosylated LAMP1, Histone H2A(K119) crotonylation, spliced XBP1, non-phospho-beta-Catenin, CD47, HMGCR and deY-Tubulin and positively affect the abundance of phospho-AKT, Histone H3(K27) trimethylation, IRF1 and PD-L1 in CMTM6 knockout