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In 5 screen(s) in human haploid (HAP1) cells CYCS was found to be regulator. Specifically, CYCS was found to negatively affect the abundance of Histone H2A(K119) crotonylation and phospho-p38 and positively affect the abundance of glycosylated LAMP1, PD-L1 and PD-L1 in CMTM6 knockout