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In 7 screen(s) in human haploid (HAP1) cells CYB5B was found to be regulator. Specifically, CYB5B was found to negatively affect the abundance of glycosylated LAMP1, phospho-p38 and HMGCR and positively affect the abundance of phospho-ERK, GNB1, phospho-AKT in KCTD5 knockout and CD47