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In 4 screen(s) in human haploid (HAP1) cells COX20 was found to be regulator. Specifically, COX20 was found to negatively affect the abundance of GNB1, Histone H3(K27) trimethylation and Histone H2A(K119) crotonylation and positively affect the abundance of PD-L1 in CMTM6 knockout