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In 7 screen(s) in human haploid (HAP1) cells COX15 was found to be regulator. Specifically, COX15 was found to negatively affect the abundance of phospho-ERK, GNB1, Histone H3(K27) trimethylation, phospho-p38 and CD47 and positively affect the abundance of PD-L1 in CMTM6 knockout and deY-Tubulin