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In 6 screen(s) in human haploid (HAP1) cells CNOT4 was found to be regulator. Specifically, CNOT4 was found to positively affect the abundance of phospho-ERK, GNB1, GNB1 in KCTD5 knockout, Histone H2A(K119) crotonylation, non-phospho-beta-Catenin and HMGCR