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In 9 screen(s) in human haploid (HAP1) cells CNOT3 was found to be regulator. Specifically, CNOT3 was found to negatively affect the abundance of phospho-ERK, phospho-AKT, Histone H2A(K119) crotonylation, non-phospho-beta-Catenin, PD-L1, CD47, HMGCR and deY-Tubulin and positively affect the abundance of glycosylated LAMP1