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In 9 screen(s) in human haploid (HAP1) cells CHIC2 was found to be regulator. Specifically, CHIC2 was found to negatively affect the abundance of phospho-ERK, GNB1, GNB1 in KCTD5 knockout, non-phospho-beta-Catenin, phospho-p38, PD-L1, IRF1 and PD-L1 in CMTM6 knockout and positively affect the abundance of phospho-AKT in KCTD5 knockout