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In 5 screen(s) in human haploid (HAP1) cells C16orf72 was found to be regulator. Specifically, C16orf72 was found to negatively affect the abundance of non-phospho-beta-Catenin and positively affect the abundance of phospho-ERK, phospho-AKT, PD-L1 and PD-L1 in CMTM6 knockout